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Updated: Jun 19, 2026
No. of Questions: 204 Questions & Answers with Testing Engine
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American Society of Microbiology ABMM Sample Questions:
1. A patient with a history of chronic sinusitis develops a severe invasive fungal infection involving the nasal sinuses and extending into the orbit. Tissue biopsy reveals broad, aseptate hyphae with irregular branching.
The patient is diabetic and acidotic. The MOST likely causative organism belongs to the genus:
A) Fusarium
B) Aspergillus
C) Mucor or Rhizopus
D) Scedosporium
2. A patient with a history of recurrent sinopulmonary infections and bronchiectasis is diagnosed with primary ciliary dyskinesia. Sputum cultures are most likely to persistently grow which of the following organisms?
A) Streptococcus pneumoniae
B) Haemophilus influenzae
C) Moraxella catarrhalis
D) Pseudomonas aeruginosa
3. A patient presents with a chronic cough, weight loss, and night sweats. Chest X-ray shows cavitarylesions in the upper lobes. Sputum is acid-fast positive. Drug susceptibility testing reveals resistance to isoniazid but susceptibility to rifampin, ethambutol, and pyrazinamide. The MOST appropriate treatment regimen should include:
A) Isoniazid and rifampin
B) Isoniazid, rifampin, pyrazinamide, and ethambutol
C) Isoniazid, ethambutol, and pyrazinamide
D) Rifampin, ethambutol, and pyrazinamide
4. The gut microbiome has been implicated in the pathogenesis of autoimmune diseases. Dysbiosis, a disruption in the composition and function of the gut microbiota, can lead to increased intestinal permeability and the translocation of microbial products that trigger inflammatory responses. Which of the following bacterial components is a potent activator of the innate immune system and has been linked to the development of autoimmunity?
A) Lipoteichoic acid (LTA)
B) Lipopolysaccharide (LPS)
C) Flagellin
D) Peptidoglycan
5. A research team is investigating the host immune response to Mycobacterium tuberculosis. They discover that a specific mycobacterial glycolipid inhibits the maturation of phagosomes containing the bacteria, preventing their fusion with lysosomes. This mechanism allows M. tuberculosis to:
A) Induce the production of pro-inflammatory cytokines.
B) Evade detection by Toll-like receptors on macrophages.
C) Escape from the phagolysosome into the cytoplasm.
D) Survive and replicate within macrophages.
Solutions:
| Question # 1 Answer: C | Question # 2 Answer: B | Question # 3 Answer: D | Question # 4 Answer: B | Question # 5 Answer: D |
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